Carhart-Harris and Friston's REBUS model (2019), relaxed beliefs under psychedelics, holds that 5-HT2A agonism relaxes the precision of high-level priors, letting bottom-up signal flood the hierarchy; the self-model, being the heaviest prior, relaxes most dramatically. Documented correlates: DMN disintegration tracks ego dissolution scores (Carhart-Harris 2016), cortical entropy rises and predicts later increases in openness (Lebedev 2016), and therapeutic outcomes correlate with dissolution intensity. The Ego Dissolution Inventory quantifies it.
The folk reading: the psychedelic renaissance validated the perennial philosophy, Griffiths's mystical-experience scores predicting depression remission reads like the desert fathers with statistics. The counter-folk reading, from clinicians, warns that dissolution without integration is just depersonalization with better marketing.
The claim: ego dissolution is the temporary lifting of the reducing valve, which is why the state schedules the wrenches. The trap literature adds the warning label: an open valve inside a prison is still inside the prison.
When the self can be dialed down pharmacologically, is the mystical experience explained, or finally measurable?